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Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia.
Supper E, Rudat S, Iyer V, Droop A, Wong K, Spinella JF, Thomas P, Sauvageau G, Adams DJ, Wong CC. Supper E, et al. Nat Commun. 2021 Apr 30;12(1):2482. doi: 10.1038/s41467-021-22750-8. Nat Commun. 2021. PMID: 33931647 Free PMC article.
Here, we demonstrate that elevated levels of the anti-apoptotic factor, CASP8 and FADD-like apoptosis regulator (CFLAR), promotes apoptosis evasion in acute myeloid leukemia (AML) cells haploinsufficient for the cut-like homeobox 1 (CUX1) …
Here, we demonstrate that elevated levels of the anti-apoptotic factor, CASP8 and FADD-like apoptosis regulator (CFLAR), promotes apo …
Association between DNA Methylation in the Core Promoter Region of the CUT-like Homeobox 1 (CUX1) Gene and Lambskin Pattern in Hu Sheep.
Lv X, Li Y, Chen W, Wang S, Cao X, Yuan Z, Getachew T, Mwacharo J, Haile A, Li Y, Sun W. Lv X, et al. Genes (Basel). 2023 Sep 26;14(10):1873. doi: 10.3390/genes14101873. Genes (Basel). 2023. PMID: 37895221 Free PMC article.
CUT-like homeobox 1 (CUX1) has been proven to be a key regulator in sheep hair follicle development. ...The results show that the core promoter region of CUX1 was present at (-1601-(-1) bp) upstream of the transcription start site. …
CUT-like homeobox 1 (CUX1) has been proven to be a key regulator in sheep hair follicle development. ...T …
Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression.
Cao Y, Deng B, Zhang S, Gao H, Song P, Zhang J, Zhao J. Cao Y, et al. Acta Biochim Biophys Sin (Shanghai). 2021 Dec 8;53(12):1713-1722. doi: 10.1093/abbs/gmab151. Acta Biochim Biophys Sin (Shanghai). 2021. PMID: 34718370 Free article.
Importantly, APS enables insulin sensitization in brown adipocytes, which may proceed through activation of the canonical phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway and AMP-activated protein kinase (AMPK). Furthermore, the level of cut- …
Importantly, APS enables insulin sensitization in brown adipocytes, which may proceed through activation of the canonical phosphatidylinosit …
Cut-like homeobox 1 and nuclear factor I/B mediate ENGRAILED2 autism spectrum disorder-associated haplotype function.
Choi J, Ababon MR, Matteson PG, Millonig JH. Choi J, et al. Hum Mol Genet. 2012 Apr 1;21(7):1566-80. doi: 10.1093/hmg/ddr594. Epub 2011 Dec 16. Hum Mol Genet. 2012. PMID: 22180456 Free PMC article.
Mass spectrometry identified these proteins as the transcription factors, Cut-like homeobox 1 (Cux1) and nuclear factor I/B (Nfib). Subsequent antibody supershifts and chromatin immunoprecipitations demonstrated that human CUX1 and NFIB b …
Mass spectrometry identified these proteins as the transcription factors, Cut-like homeobox 1 (Cux1) and …
Distinct clinical and biological implications of CUX1 in myeloid neoplasms.
Aly M, Ramdzan ZM, Nagata Y, Balasubramanian SK, Hosono N, Makishima H, Visconte V, Kuzmanovic T, Adema V, Nazha A, Przychodzen BP, Kerr CM, Sekeres MA, Abazeed ME, Nepveu A, Maciejewski JP. Aly M, et al. Blood Adv. 2019 Jul 23;3(14):2164-2178. doi: 10.1182/bloodadvances.2018028423. Blood Adv. 2019. PMID: 31320321 Free PMC article.
Somatic mutations of the CUT-like homeobox 1 (CUX1) gene (CUX1 (MT)) can be found in myeloid neoplasms (MNs), in particular, in myelodysplastic syndromes (MDSs). ...CUX1 (MT) were present in 4% of chronic MNs. CUX1 (DEL) wer …
Somatic mutations of the CUT-like homeobox 1 (CUX1) gene (CUX1 (MT)) can be found in myeloid neopl …
Proteolytic processing of cut homeobox 1 by neutrophil elastase in the MV4;11 myeloid leukemia cell line.
Goulet B, Markovic Y, Leduy L, Nepveu A. Goulet B, et al. Mol Cancer Res. 2008 Apr;6(4):644-53. doi: 10.1158/1541-7786.MCR-07-0268. Mol Cancer Res. 2008. PMID: 18403643
Proteolytic processing by cathepsin L generates p110 Cut homeobox 1 (CUX1) at the end of the G(1) phase, whereas an alternative transcript encodes p75 CUX1. These short CUX1 isoforms were reported to be overexpressed in cancer cell …
Proteolytic processing by cathepsin L generates p110 Cut homeobox 1 (CUX1) at the end of the G(1) phase, …
Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression.
Li H, Yang F, Hu A, Wang X, Fang E, Chen Y, Li D, Song H, Wang J, Guo Y, Liu Y, Li H, Huang K, Zheng L, Tong Q. Li H, et al. EMBO Mol Med. 2019 Dec;11(12):e10835. doi: 10.15252/emmm.201910835. Epub 2019 Nov 11. EMBO Mol Med. 2019. PMID: 31709724 Free PMC article.
However, the mechanisms regulating glycolytic gene expression remain elusive in neuroblastoma (NB), the most common extracranial malignancy in childhood. Herein, we identify that CUT-like homeobox 1 (CUX1) and CUX1-generated circular RNA …
However, the mechanisms regulating glycolytic gene expression remain elusive in neuroblastoma (NB), the most common extracranial malignancy …
Cux1(+) proliferative basal cells promote epidermal hyperplasia in chronic dry skin disease identified by single-cell RNA transcriptomics.
Huang M, Hua N, Zhuang S, Fang Q, Shang J, Wang Z, Tao X, Niu J, Li X, Yu P, Yang W. Huang M, et al. J Pharm Anal. 2023 Jul;13(7):745-759. doi: 10.1016/j.jpha.2023.04.004. Epub 2023 Apr 11. J Pharm Anal. 2023. PMID: 37577389 Free PMC article.
Here, we used scRNA-seq and in situ hybridization to identify a novel proliferative basal cell (PBC) state that exclusively expresses transcription factor CUT-like homeobox 1 (Cux1). Further in vitro study demonstrated that Cux1 is vital …
Here, we used scRNA-seq and in situ hybridization to identify a novel proliferative basal cell (PBC) state that exclusively expresses transc …
CUX1, a haploinsufficient tumour suppressor gene overexpressed in advanced cancers.
Ramdzan ZM, Nepveu A. Ramdzan ZM, et al. Nat Rev Cancer. 2014 Oct;14(10):673-82. doi: 10.1038/nrc3805. Epub 2014 Sep 5. Nat Rev Cancer. 2014. PMID: 25190083 Review.
CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour suppression and progression. ...One CUX1 isoform functions as an ancillary factor in base excision repair and the other CUX1 isoforms act as tra …
CUT-like homeobox 1 (CUX1) is a homeobox gene that is implicated in both tumour suppression and pr …
p113 isoform encoded by CUX1 circular RNA drives tumor progression via facilitating ZRF1/BRD4 transactivation.
Yang F, Hu A, Guo Y, Wang J, Li D, Wang X, Jin S, Yuan B, Cai S, Zhou Y, Li Q, Chen G, Gao H, Zheng L, Tong Q. Yang F, et al. Mol Cancer. 2021 Sep 27;20(1):123. doi: 10.1186/s12943-021-01421-8. Mol Cancer. 2021. PMID: 34579723 Free PMC article.
Gain- and loss-of-function studies were performed to observe the impacts of circRNA-encoded protein and its partners on the lipid metabolism, mitochondrial activity, growth, invasion, and metastasis of NB cells. RESULTS: A novel 113-amino acid protein (p113) of CUT-like …
Gain- and loss-of-function studies were performed to observe the impacts of circRNA-encoded protein and its partners on the lipid metabolism …
39 results